摘要
观察糖络宁对糖尿病性周围神经病变 (DPN)的临床疗效并对其作用机制进行探讨。符合标准的DPN病人 4 8例 ,随机分为治疗组和对照组 ,在基础治疗的基础上 ,治疗组予具有益气养阴、滋补肝肾、活血通络的糖络宁治疗 ,对照组予口服弥可保 (甲钴胺 )治疗。对病人的症状、神经传导速度、微循环、红细胞内山梨醇含量进行了观察。结果 :治疗组的总有效率为 91 67% ,优于对照组的62 5 0 % (P <0 0 1)。糖络宁对DPN病人的肢体麻木、疼痛、痉挛、踝反射减弱等神经系统症状改善明显 ,对神经传导速度和末梢微循环积分有明显的改善作用 ,红细胞内山梨醇含量也有显著降低 ,在治疗过程中未见明显的不良反应。
The clinical efficacy of Tangluoning for treating diabetic peripheral neuropathy (DPN) and the mechanism of the efficacy were investigated. 48 DPN patients conforming to the diagnostic criteria were randomly divided into the treating group and control group. On the basis of basic treatment, the former was given Tangluoning (for benefiting qi and nourishing yin, tonifying the liver and kidney, and activating blood circulation), and the latter was given methycobal (mecobalamin). The changes in the symptoms, nerve conduction velocity (NCV), microcirculation in the limbs and the content of sorbitol in the red blood cells (RBC) were observed in the patients. The results showed that the total effective rate of the treating group was 91 67% and that of the control group, 62 50%, and there was a significant difference between the two rates ( P <0 01). The results also showed that Tangluoning could markedly relieve the symptoms such as numbness of the limbs, pain, spasm, weakened ankle reflex, improve the nerve conductive velocity and microcirculation of the limbs and decrease the content of sorbitol in RBC, with no obvious side effects found during the treatment.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2002年第4期59-62,共4页
Journal of Beijing University of Traditional Chinese Medicine
