期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管生成抑制素canstatin的新发现 被引量：6

Canstatin: a novel inhibitor of angiogenesis
下载PDF
导出
摘要 AIM: As a human basement membrane-derived inhibitor of angiogenesis and tumor growth, canstatin has been paid great attention since it was isolated and identified in 2000. Canstatin significantly inhibited human endothelial cell migration and proliferation and induced apoptosis, suggesting that it might be a powerful and potential therapeutic molecule for atherosclerosis,unstable angina and tumor. AIM: As a human basement membrane-derived inhibitor of angiogenesis and tumor growth, canstatin has been paid great attention since it was isolated and identified in 2000. Canstatin significantly inhibited human endothelial cell migration and proliferation and induced apoptosis, suggesting that it might be a powerful and potential therapeutic molecule for atherosclerosis,unstable angina and tumor.
作者 李浪 冯建章 郑文岭
机构地区 广东省心血管病研究所广东省人民医院霍英东心脏中心心内科 广西医科大学心血管病研究所心内科 广州军区总医院分子肿瘤研究所
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2002年第7期862-864,共3页 Chinese Journal of Pathophysiology
关键词 血管生成抑制素 CANSTATIN 血管生成因子 血管内皮 动脉粥样硬化 Angiogenesis factor \ Endothelium, vascular \ Atherosclerosis
分类号 R979.1 [医药卫生—药品] R543.5 [医药卫生—药学]
  • 相关文献

参考文献10

  • 1[1]Kamphaus GD, Colorado PC, Panka DJ, et al . Canstatin, anovel matrix - derived inhibitor of angiogenesis and tumorgrowth.[J] J Biol Chem, 2000,275(2):1209- 1215. 被引量：1
  • 2[2]Barinaga M. Desiging therapies that target tumor blood vessels[J]. Science, 1997, 275(5299) :482- 484. 被引量：1
  • 3[3]Haralabopoulos GC, Grant DS, Kleinman HK, et al. Inhibitorsof basement membrane collagen synthesis prevent endothelialcell aligment in matrigel in vitro and angiogenesis in vivo[J].Lab Invest , 1994,7 (4) : 575- 582. 被引量：1
  • 4[4]Timpl R. Macromolecular organization of basement membranes[J]. Curr Opin Cell Biol, 1996,8 (5):618 - 624. 被引量：1
  • 5[5]Tsilibary EC, Reger LA, Vogel AM.. et al . Identification of amultifunctional, cell binding peptide sequence from the αl(NCI) of tyre Ⅳ collagen[J]. J cell Biol, 1990,111 (4):1583- 1591. 被引量：1
  • 6[6]Neilson EG, Kalluri R, Sun MJ, et al. Specificity of goodpasture autoantibotidies for the recombinant noncollagenous domains of human type Ⅳ collagen[J]. J Biol Chem, 1993, 268(12):8402-8405. 被引量：1
  • 7[7]Brooks PC, Clark RA, Cheresh DA. Requirement of vascularintegrin alpha V beta 3 for angiogenesis[J]. Science, 1994,264 (5158): 569- 571. 被引量：1
  • 8[8]Chen YX,Nakashima Y,Tanaka K,et al. Immunohistochemicalexpression of vascular endothelial growth factor/vascular permeability factor in atherosclerotic intimals of human coronaryarteries[J]. ATVB, 1999, 19(1) :131 - 139. 被引量：1
  • 9[9]Moulton KS, Heller E, kinerding MA, et al. Angiogenesis inhibitors endostatin or TNP - 470 reduce intimal neovascularization and plaque growth in apoliipoprotein E - deficient mice[J]. Circulation, 1999,99 (13) :1726 - 1732. 被引量：1
  • 10[10]Tenaglia AN, Peters KG, Sketch MN, et al. Neovascularization in atherectomy specimens from patients with unstableangina: implications from pathogenesis of unstable angina[J].Am Heart J, 1998,135(1): 10 - 14. 被引量：1

同被引文献43

引证文献6

二级引证文献15

中国病理生理杂志
2002年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部