摘要
目的 评价低分子肝素(Low Molecular Weight Heparin,LMWH)预防髋、膝关节手术后深静脉血栓形成(Deep Venous Thrombosis,DVT)的疗效和安全性。方法 前瞻性地将46例接受髋、膝关节手术的患者,随机分成二组。一组应用低分子肝素(速避凝)预防,另一组作为对照。术后第4～7天内行患侧静脉造影检查了解深静脉血栓的发生情况。结果 对照组23例患者中有8例(34.8％)发生DVT;而治疗组23例中仅1例(4.3％)发生DVT(P<0.05)。两组中均未发生明显的出血并发症。结论 低分子肝素能安全、有效地预防髋、膝关节术后深静脉血栓形成。
Objective To evaluate the efliciency and safety of low molecular weight heparin (LMWH) in prophylaxis of postoperative deep vein thrombosis (DVT) following hip and knee surgery. Methods 46 patients undergoing hip and knee orthopaedic procedures were randomized into 2 groups for deep vein thrombosis prophylaxis. One group were controled; another group received subcutaneously a low molecular weight heparin (Fraxiparine) with anti-factor Xa activity of 41 IU ?kg-1 ·day-1 for three days, then 62 IU · kg-1 ·day-1 from day 4 to day 10. All patients had venography performed in the operated leg 4-7 days after surgery. Results 8 patients ( 34. 8% ) developed DVT in the control group of 23 patients and 1 patient ( 4. 3% ) in the treatment group, also of 23 patients (P < 0. 05). Two groups had no any bleeding complications . Conclusions: Our study confirms the safety and efficien of low molecular weight heparin in preventing postoperative deep vein thrombosis in patients following hip and knee surgery.
关键词
低分子量肝素
预防
髋膝术
下肢深静脉血栓形成
Low molecular weight heparin (LMWH) Deep Vein Thrombosis (DVT) Prophylaxis
