摘要
In the clinical field,insulin has been used for treatment of diabetes.However,insulin often shows low physicochemical stability,adsorption onto tubes and enzymatic degradation in injection site or blood.Previously,we demonstrated that cyclodextrins(CyDs),especially branchedβ-CyDs,improve the pharmaceutical properties of insulin through complexation with its aromatic residues.However,little has been reported on the insulin conjugate with branchedβ-CyD.In the present study,to improve the pharmaceutical properties of insulin,we newly prepared 6-Ο-α-(4-Ο-α-D-glucuronyl)-D-glucosyl-β-CyD(GUG-β-CyD)conjugate with insulin,and evaluated its thermal or enzymatic stability and adsorption onto glass or polypropylene tube[1].
