摘要
目的探讨牙周治疗对孕期牙周指数及血清白细胞介素-1(IL-1)水平的影响。方法选择60例中期妊娠妇女为研究对象,其中牙周炎30例,健康对照者30例。牙周炎组进行牙周治疗,分别与治疗前及治疗后4~6周检查菌斑指数(PLI)、探诊深度(PD)、临床附着丧失(CAL)和出血指数(BI);同时抽取空腹静脉血5 mL,以ELISA法测定血清IL-1水平。结果牙周炎组和对照组之间,PLI、PD、CAL、BI和血清IL-1差异均有统计学意义(P<0.05);治疗后牙周炎组牙周状况明显改善(P<0.05)且与正常对照组间差异无统计学意义(P>0.05),血清IL-1水平较治疗前下降明显(P<0.05),与正常对照组间差异无统计学意义(P>0.05)。结论牙周治疗可降低孕期血清IL-1水平,改善牙周状况。
Objective To investigate the influence of periodontal treatment to the periodontal index and the serum Interleukin-1 (IL-1 )levels in pregnancy.Method Based on the periodontal health status,60 women in median pregnancy were enrolled and categorized as pe-riodontitis (PG,n=30),and control group (CG,n=30).The clinical periodontal measurements,including plaque index(PLI),probing depth (PD),clinical attachment loss (CAL),bleeding index(BI).Meanwhile,fasting peripheral blood sample was collected by venipuncture before periodontal treatment and after 4 to 6 weeks.The serum IL-1 level was quantified by ELISA.Result The serum IL-1 levels and each of the clinical parameters were significantly higher in PG group than those in CG group (P<0.05).After treatment,periodontal status improved sig-nificantly in PG group (P<0.05),between the CG the difference was not statistically significant (P>0.05).There is significant decrease in levels of IL-1at PG after periodontal treatment(P<0.05),between the CG the difference was not statistically significant (P>0.05).Conclu-sion Periodontal treatment during pregnancy can reduce the serum levels of IL-1 and improve the periodontal status.
出处
《安徽医学》
2014年第7期875-877,共3页
Anhui Medical Journal
基金
安徽省科技厅年度重点科研项目(11070403047)
合肥市第四周期医学重点学科建设计划资助项目[卫科(2013)237号]
