摘要
目的 :观察高强度聚焦超声热疗前后恶性肿瘤患者血清可溶性白介素 2受体 (sIL 2R)、白介素 8(IL 8)、γ 干扰素 (γ IFN)的变化及其意义。方法 :采用双抗夹心ELISA法测定 2 7例恶性肿瘤患者热疗前后血清sIL 2R、IL 8、γ IFN水平。结果 :热疗后患者血清sIL 2R水平显著降低 (t=2 .2 5 ,P <0 .0 5 ) ,IL 8水平显著增高 (t=1.83,P <0 .0 5 ) ,γ IFN显著升高 (t=2 .2 3,P <0 .0 5 ) ,并观察到热疗后患者临床症状得到明显改善。结论 :高强度聚焦超声热疗可以降低恶性肿瘤患者血清sIL 2R水平 ,提高IL 8、γ IFN的水平 ,从而有助于解除恶性肿瘤患者的免疫抑制。
Aim: To study the changes of soluble interleukin 2 receptor(sIL-2R), interleukin 8 (IL-8) and interferin-γ (γ-IFN) of patients with malignant tumor after hyperthermia with high intensity focused ultrasound. Methods: The changes of sIL-2R, IL-8,and γ-IFN of 27 patients with malignant tumor were evaluated before and after hyperthermia by ELISA. Results: Compared with those before hyperthermia,the level of sIL-2R was significantly lower, and those of IL-8 and γ-IFN were significantly higher after hyperthermia (P<0.05).Besides, the clinical symptoms of the patients were improved. Conclusion: Evaluating the levels of sIL-2R, IL-8 and, IFN-γ is helpful to know the state of immunity of patients with malignant trmor, and the 3 indexes may be the reference marks of prognosis
出处
《郑州大学学报（医学版）》
CAS
北大核心
2002年第4期455-457,共3页
Journal of Zhengzhou University(Medical Sciences)
