摘要
目的 :探讨血清急性时相蛋白变化在胃癌术后复发早期诊断中的价值。方法 :检测 12 0名胃癌患者手术前、后血清急性时相蛋白的水平 ;对行胃癌根治术的 87名患者 ,分别根据术后 6个月血清C反应蛋白 (CRP)、α1 抗胰蛋白酶 (α1 AT)和α 酸性糖蛋白 (α AG)水平进行分组 ,观察其复发情况 ,至少随访 12个月或至死亡。结果 :胃癌组血清CRP、α1 AT和α AG水平显著高于对照组 ,铜蓝蛋白 (CER)、转铁蛋白 (TFR)和前白蛋白 (PAB)水平未见显著变化 ;胃癌术后一定时期血清CRP、α1 AT和α AG水平显著低于术前水平 ,其他指标未见显著改变 ;CRP阳性组复发率 (6 /10 )显著高于阴性组 (11/77) ,α1 AT阳性组复发率 (7/11)显著高于阴性组 (10 /76 ) ,α AG阳性组复发率 (6 /13)显著高于阴性组 (11/74)。结论 :急性时相蛋白可作为肿瘤复发的预测因子 ,检测急性时相蛋白可为胃癌术后复发早期诊断提供可靠的临床信息。
Aim: To explore the value of acute-phase protein measurement at the early stage of recurrence in diagnosis after curative gastric cancer surgery. Methods: Acute-phase serum protein levels were measured before and after curative gastric cancer surgery in 120 patients. At 6 months after surgery,87 patients were grouped according to the levels of C-reactive protein(CRP), α 1-antichymotrypsin(α 1-AT) and α-acid glycoprotein(α-AG),and were followed up for more than 12 months or until death. Results: The levels of serum CRP, α 1-AT,and α-AG in patients with gastric cancer were significantly higher (P<0.05) than that in control group while those of CER, TER and PAB had no significant difference. In a certain period, serum levels of acute-phase protein in patients after surgery were significantly lower than those before surgery (P<0.05).The recurrence rates in CRP positive group,α 1-AT positive group, and α-AG positive group were significantly higher than their corresponding negative groups. Conclusion: An acute-phase protein response may be a predictive factor at the early stages of gastric carcinoma recurrence. Acute-phase protein measurements clinically provide useful information about tumor recurrence after curative gastric cancer surgery.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2002年第4期447-449,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省科技攻关资助项目 0 2 2 46 30 0 38
关键词
胃癌
急性时相蛋白
肿瘤复发
检测
gastric cancer
acute-phase protein
carcinoma recurrence
