摘要
目的 :观察布地奈德干粉吸入剂 (商品名 :普米克都保 )吸入治疗支气管哮喘的疗效及起效时间。方法 :将 38例哮喘缓解期患者随机分为 2组 :试验组 18例 ,吸入普米克都保 4 0 0 μg ,bid ;对照组 2 0例 ,口服茶碱控释胶囊 (商品名 :时尔平 ) 0 .2 g ,bid ,2组均按需使用沙丁胺醇气雾剂 (商品名 :喘乐宁 ) ,疗程均为 8周 ,治疗前后观察哮喘症状 ,测定肺功能 ,对普米克都保组其中 8例进行每日晨晚PEFR监测。结果 :试验组治疗 2周后 ,其用力肺活量 (FVC) ,1s用力呼气量 (FEV1 ) ,最大呼气流量 (PEFR) ,用力呼气中期流量 (FEF2 5～ 75)和 5 0 %肺活量 (V50 )均有明显改善 (P <0 .0 1) ,随治疗时间延长 ,肺功能进一步改善 ,对照组上述指标无明显变化。吸入普米克都保治疗 4d ,每日晨晚PEFR值即有明显升高 (P <0 .0 5 )。结论 :普米克都保能及时有效地治疗支气管哮喘。
Objective:To observe the efficacy of budesonide dry powder inhalant (Pulmicort Turbuhaler) in treatment of bronchial asthma.Methods:38 interval phase patients with bronchial asthma were assigned to 2 groups.The test group( n =18) was treated with Pulmicort Turbuhaler (400μg,bid) puls salbutamol aerosol as needed for 8 weeks.The control group ( n =20) was treated with theophylline controlled release capsule (0.2g, bid) puls salbutamol aerosol as needed for 8 weeks.The symptoms of asthma and pulmonary function was observed before and after treatment.The peak expiratory flow rate (PEFR) of 8 patients in the test group were exmined daily before and after treatment.Results:Pulmicort Turbuhaler significantly increased FVC,FEV 1,PEFR,FEF 25～75 ,V 50 ( P < 0.01)after 2 weeks treatment.The pulmonary function was further improved with the rise of inhalation.There was no significant changes in the control group.Daily PEFR was significantly increased ( P <0.05) after 4 days Pulmicort Turbuhaler treatment.Conclusion:Pulmicort Turbuhaler is effective in treatment of bronchial asthma.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第7期557-559,共3页
Chinese Journal of New Drugs
关键词
布地奈德干粉吸入剂
治疗
支气管哮喘
bronchial asthma
budesonide
dry powder inhalant
pulmonary function
