摘要
目的 :研究三叶委陵菜乙醇提取物的镇痛作用。方法 :热板法和扭体法。结果 :热板法中 ,灌胃三叶委陵菜乙醇提取物 (0 5 g/kg ,1 2 5 g/kg ,2 5g/kg) 15 ,3 0 ,60和 90min后 ,小鼠的痛阈均明显延长 ,其中灌胃 2 5g/kg提取物 90min后的镇痛效应比氨基比林 (10 0mg/kgi.m .)的好。在对非甾体药敏感的扭体法中 ,不同剂量的三叶委陵菜醇提物 (0 5 g/kg ,1 2 5 g/kg ,2 5 g/kgo .p .)均能显著抑制 0 7%醋酸引起的扭体反应。 结论 :三叶委陵菜具有镇痛效应 ,民间用三叶委陵菜医治牙痛及其它疼痛症的疗效得到了验证。
Objective:To evaluate the analgesic effect from the ethanolic extract of Potentilla freyniana Bornm. var. Sinica Migo (PBSM).Methods:The analgesic properties of PBSM were investigated by the classical hot plate test and the writhing test.Results:In the hot plate test,the ethanolic extract of PBSM(0 5g/kg,1.25 g/kg,2 5g/kg,o.p.) significantly delayed the response time to hot-plate thermal stimulation 15,30,60 and 90 min after treatment,and 90 min after treatment,the effect of PBSM (2 5g/kg) was higher than that of aminopyrine (100 mg/kg i.m.).In the writhing test, which is more sensitive for non-steroidal analgesics, the ethanolic extract of PBSM (0 5g/kg,1 25g/kg,2 5g/kg o.p.) dose significantly inhibited the writhes induced by 0 7% acetic acid.Conclusion:Potentilla freyniana Bornm.var.Sinica Migo may have analgesic activity and affirm the claim by traditional medicine practitioners of the use in toothache or some painful conditions.
出处
《江苏临床医学杂志》
2002年第3期200-203,共4页
Journal of Jiangsu Clinical Medicine
关键词
三叶委陵菜
镇痛作用
热板法
扭体法
动物实验
Potentilla freyniana Bornm.var.Sinica Migo
Analgesic activity
Hot plate
Writhing test
