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Changes of IL-8 and IL-8 mRNA after blast-fragment combined injury in dogs 被引量：1

Changes of IL-8 and IL-8 mRNA after blast-fragment combined injury in dogs
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摘要 Objective:To explorethe characteristicsand the mechanismof the blast-fragmentcombinedinjury.Methods:Afterthedogswereinflictedwithhigh-velocityfragmentinjuryon theirlefthindlimbsafterblastinjury,theIL-8intheplasmaandlungtissuesupernatantswereassayedwithELISA,andtheexpressionof IL-8mRNAin lungtissuewas detectedwithin situ hybridization.Results:The levelsof IL-8in plasmaandlungtissueswere increasedafterblast,highvelocityfragmentandblast-fragmentcombinedinjuriesrespectively.IL-8mRNAwere upregulatedafterinjuries.Conclusion:IL-8may playa rolein theoccurrenceanddevelopmentof lunginjury.Detectingtheplasmalevelsof IL-8maybe quitehelpfulto estimatetheinjury. Objective:To explorethe characteristicsand the mechanismof the blast-fragmentcombinedinjury.Methods:Afterthedogswereinflictedwithhigh-velocityfragmentinjuryon theirlefthindlimbsafterblastinjury,theIL-8intheplasmaandlungtissuesupernatantswereassayedwithELISA,andtheexpressionof IL-8mRNAin lungtissuewas detectedwithin situ hybridization.Results:The levelsof IL-8in plasmaandlungtissueswere increasedafterblast,highvelocityfragmentandblast-fragmentcombinedinjuriesrespectively.IL-8mRNAwere upregulatedafterinjuries.Conclusion:IL-8may playa rolein theoccurrenceanddevelopmentof lunginjury.Detectingtheplasmalevelsof IL-8maybe quitehelpfulto estimatetheinjury.
作者 严家川 杨志焕 董蕻 冯刚 李晓炎 尹友国
出处 《Journal of Medical Colleges of PLA(China)》 CAS 2001年第2期83-85,共3页 中国人民解放军军医大学学报（英文版）
关键词 blastinjury fragmentinjury blast-fragmentcombinedinjury INTERLEUKIN-8 爆炸性损伤 碎片性损伤 复合损伤 白介素8 mRNA
分类号 R392.1 [医药卫生—免疫学]
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Journal of Medical Colleges of PLA(China)
2001年 第2期

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