摘要
目的 观察应用降纤酶治疗急性缺血性脑血管病的疗效。 方法 将急性缺血性脑血管病患者10 5例 ,随机分为治疗组和对照组。治疗组 5 4例 ,用降纤酶 10 u (体重在 60 kg以下者 5 u)加生理盐水 2 5 0 ml静脉滴注 ,每天 1次 ,连用 3天 ,第 4天后改为隔日静滴 1次 ,降纤酶总量达到 60 u;对照组 5 1例 ,用复方丹参 2 0 ml加 0 .9%生理盐水 2 5 0 ml静脉滴注 ,每天 1次 ,连用 14天为 1个疗程。于治疗后第 7天、第14天检测两组治疗前后的神经功能缺损评分和日常生活能力评分 ,以评价其临床疗效。 结果 治疗组的有效率和显效率分别达到 87.0 3 %和 62 .9% ,而对照组的有效率和显效率分别为 60 .78%和 3 7.2 5 % ,两组比较有显著性差异 (P <0 .0 5 )。两组治疗后的日常生活能力和神经功能缺损评分均有显著性差异 (P<0 .0 1) ,血液流变学等指标均有明显的改善 (P <0 .0 1)。 结论 降纤酶具有降低血浆纤维蛋白原、改善微循环、降低全血粘度等作用 ,是治疗急性缺血性脑血管病安全。
Objective To observe the efficacy of defibrase treating to acute cerebral infaction Methods The 105 patients were divided into two groups randomly Patients(n=54) as treatment group were treated with defibrase 10u added to 0 9% normal sodium 250ml,iv drip,once daily for 3 days,4 days later once every the other day,altogether 60u The other 51 patients as compound group were treated with salvia miltiorrhiza20ml added to 0 9% normal sodium 250ml iv drip, qd for 14 days We examied neurological function and ability of linving before and after treatment to evaluate the efficacy Result The clinical effective rate was 87 03% in defibrase group while 60 78% in salvia miltiorrhiza There was significant difference between the group(P<0 05) Defibrase group's curative effect was better than of salvia miltiorrhiza compound group Defibrase can remarkably improve the sooring of neurological function and ability of living Conclusion Defibrase can remarkably reduce fibrnogn blood viscosity and improve microciculation Defibrase is safe and effective drus for the treatment of cerebral infarction
出处
《蛇志》
2002年第2期18-20,共3页
Journal of Snake
关键词
降纤酶
治疗
急性缺血性脑管病
疗效观察
acute cerebral infaction
defibrase
salvia miltiorrhiza
clinical observation
