摘要
目的 了解青蒿琥酯分别与氯喹、克林霉素联用对抗药性恶性疟的疗效。 方法 在中老、中缅边境抗药恶性疟流行区 ,采用青蒿琥酯与氯喹 (A组 )或克林霉素 (B组 )联用 3d疗法治疗和观察无并发症的恶性疟。 结果 共完成96例观察 ,A组 34例、B组 6 2例 ,平均退热时间分别为 (2 8.6± 13.9) h和 (2 8.3± 18.7) h;平均原虫无性体转阴时间分别为 (31.8± 11.1) h及 (32 .7± 9.9) h,2 8d复燃率分别为 12 .0 % (3/ 2 5 )、13.6 % (8/ 5 9)。 结论 青蒿琥酯与氯喹或克林霉素联用对抗药性恶性疟的治疗具有一定的增效作用 ,但根治率均在 90
Objective To understand the curative effect of artesunate combined respectively with chloroquine or clindamycin against falciparum malaria. Methods In China Laos and China Myanmar border areas where is spreading chloroquine resistance falciparum malaria, the uncomplicated falciparum malaria patients were treated by artesunate combined with chloroquine (Group A) or clindamycin(Group B) with 3 day treatment method in vivo . Results 96 patients were treated by in vivo observation. Group A which had 34 cases, were treated by artesunate combined with chloroquine; Group B which had 62 cases, were treated by artesunate combined with clindamycin. The mean fever clearance time is (28.6±13.9) h and (28.3±18.7) h, the mean asexial parasite disappearance time is (31.8±11.1) h and (32.7±9.9) h; In periods of 28 d, the relapse rate is 12.0%(3/25) and 13.6%(8/59), respectively. Conclusion Artesunate combined with chloroquine or clindamycin respectively has an obvious increasing effect to chloroquine resistance falciparum malaria in vivo , but the curative rate was less than 90%.
出处
《中国寄生虫病防治杂志》
CSCD
2002年第3期135-137,共3页
Chinese Journal of Parasitic Disease Control
基金
联合国开发计划署 /世界银行 /世界卫生组织热带病研究与培训特别规划处 (ID- 971 1 4 4 )
中国云南省卫生厅资助项目 (No.980 0 7)
