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抑癌基因PTEN的结构、功能、作用机制及其研究现状 被引量:1

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出处 《广东医学》 CAS CSCD 2002年第7期763-764,共2页 Guangdong Medical Journal
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  • 1张利能,查锡良.抑癌基因PTEN及其在肿瘤中的突变失活[J].生命的化学,1999,19(2):95-97. 被引量:3
  • 2[2]Steck PA, Pershouse MA, Jasser SA, et al. Indentification of a candidate tumor suppressor gene MMAC1 at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet, 1997,15:356 被引量:1
  • 3[3]Lee JO ,Yang H, Georgescu MM, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell, 1999,99:323 被引量:1
  • 4[4]Rizo J, Sudhor TC. C2-domains, structure and function of a universal Ca2+-binging domain. J Biol Chem, 1998,273:15879 被引量:1
  • 5[5]Georgescu MM. The tumor suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci USA, 1999,96:10182 被引量:1
  • 6[6]Tolkacheva T, Chan AML. Inhibition of H-Ras tansformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene, 2000, 19:680 被引量:1
  • 7[7]Adey NB, Huang L, Ormonde PA, et al. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res, 2000, 60:35 被引量:1
  • 8[8]Wu X, Dowbenko D, Spencer S, et al. Evidence for regulation of PTEN tumor suppressor by a membrane-localized multi-PDZdomain of MAG13, a novel membrane-associated guanylate kinase. Proc Natl Acad Sci USA, 2000, 97:4233 被引量:1
  • 9[9]Wu X. Innteraction of the tumor suppressor PTEN/MMAC. Biol Chem, 2000,275:21477 被引量:1
  • 10[10]Cantley LC. New insights into tumor suppression: PTEN suppresses tumor formatoin by restraining the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci USA, 1999, 96:4240 被引量:1

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