摘要
目的 研究补钙对废用性骨质疏松仔鼠骨密度、血清TRAR和AKP的影响 ,为骨质疏松的防治提供依据。方法 选取 2 5只怀孕雌鼠单笼喂养 ,2～ 5组复制骨质疏松动物模型 ,1～ 2组喂普通饲料 ,作为对照 ,3～ 5组喂补钙实验饲料 ,仔鼠出生后 ,每窝选取 3只与母鼠同笼喂养 ,观察至仔鼠出生 37d后测其骨密度、骨矿物含量及血清TRAP和AKP。结果 各补钙组子鼠骨密度及骨矿物含量明显比阳性对照组增高。与阳性对照组相比 ,各补钙组的血清TRAP和AKP明显降低。
Objective To study the effect of Ca supplement on the mineral density(BMD),serum TRAP and AKP of osteoporosis and provide the evidence on how to treat and prevent osteoporosis.Methods Twenty five helathy pregnant SD rats were randomly divided into 5 Groups.Groups 2,3,4 and 5 were reproduced with patterns of animal osteoporosis.The diet in group 1 and group 2 was the basic diet,while the groups 3,4,5 experiment diets were supplemented with Ca.After born,selected 3 young rats live with the mother rate.The BMD,BMC,serum TRAP and AKP were measured 37 days later.Results The BMD and BMC level of young rats in Ca supplement group is higher than vigorous group.The serum TRAP and AKP in vigorous group were higher than Ca supplement group.Conclusion Ca supplement has certain effects on the prevention of osteoporosis.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2002年第7期789-790,共2页
Chinese Journal of Public Health
基金
河南省自然科学基金项目 (9640 2 1 50 0 )
关键词
骨质疏松
钙
TRAP
AKP
osteoporossi
bone mineral
density
Ca
TRAP
AKP
