摘要
目的:阐明^(125)I-青藤碱经大鼠皮肤给药后渗透和扩散的走向。方法:采用同位素^(125)I-标记青藤碱,涂于大鼠颈部皮肤,在一定时间内测定^(125)I-青藤碱在皮下纵向渗透的深度和横向扩散的范围。结果:^(125)I-青藤碱纵向扩散可达颈椎骨部,横向扩散可达2 cm^2范围,无论是横向还是纵向扩散均呈现出明显的浓度梯度。结论:^(125)-青藤碱不仅可以透皮吸收入血发挥全身作用也可在皮肤表面蓄积发挥局部作用。
Objective: To study the permeance and diffusion trend of 125I-sinomenine via the trandermal delivery way in rats. Method:Assay the permeance depth and diffusion area of sinomenine labeled by isotopic 125I in subcutaneous of rats certain time after sinomenine was administrated on the cervical skin of rats. Results: The diffuse of sionmenine can reach cervical spine in longitudinal direction and form an area of 2 cm in transverse direction.The concentration gradient of both directions are significant.Conclusion: 125I-sinomenine can not only be absorbed into blood via the trasdermal delvery way to have whole effect, but also accumulate large amounts in the skin to have a local effect.
出处
《中药材》
CAS
CSCD
北大核心
2002年第6期412-413,共2页
Journal of Chinese Medicinal Materials
基金
上海市教委资助课题(No.99L7)
