摘要
超短肽(overshort peptides,简称OSP)是一类由2～4个氨基酸组成的活性肽,存在于体内,参与多方面的生理、生化或病理过程,其中有些OSP分布于CNS,可能参与情感等高级神经活动的调节。为了探讨OSP可能的药用前景,我们对其中5个OSP进行了抗抑郁作用研究。
The antidepressant effects of 5 OSP (TRH, KTP, CHP, γDGG, and AGF) were studied with two behavior despair models in mice. Only CHP was shown to decrease the spontaneous motor activity of mice, the others almost showed no effec in open field test. TRH significantly shortened the immobility produced by tail suspension test and the persistant immobility produced by cornea electrostimulation test. This indicates that the antidepressant characteristic of TRH is very similar to amitriptyline or that amitriptyline exerts its antidepressant effect by affecting TRH in CNS.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第7期546-547,共2页
Acta Pharmaceutica Sinica
关键词
超短肽
抗抑郁作用
Thyropin- releasing hormone (TRH)
Tail suspension test: Cornea electrostimulation test
