摘要
目的 :评价窒息缺氧对新生儿瘦素、胰岛素、生长激素、甲状腺素、糖皮质激素及体重的影响。方法 :应用放射免疫法测定 2 3例 (窒息组 )中、重度窒息缺氧新生儿及无窒息 12例 (对照组 )新生儿静脉血血浆瘦素、胰岛素、生长激素、甲状腺素、皮质醇水平。结果 :窒息组新生儿出生后 5d体重增长下降 (P <0 .0 5 ) ,出生后 2 4~ 4 8h血浆生长激素、甲状腺素水平明显低于对照组 (分别P <0 .0 1,P <0 .0 5 ) ;而瘦素、皮质醇、胰岛素明显高于对照组 (分别为P <0 .0 5 ,P <0 .0 1,P <0 .0 5 )。出生后第 5d上述 5种内分泌激素水平才接近正常。结论 :窒息缺氧影响新生儿多种内分泌激素变化 ,不利于生长、发育 ,提出可能纠正的方法。
Objective: To evaluate the effect of neonatal asphyxia on leptin, insulin, growth hormone, thyroxin, corticosteoid and body weight. Methods: Twenty three newborns with moderate severe asphyxia were studied and 12 newborns without asphyxia newborns served as control. Plasma leptin, insulin, growth hormone, thyroxin, corticosteoid were measured by using radioimmunoassay.Results: Moderate severe asphyxia resulted in a significant decrease of plasma growth hormone, thyroxin ( P <0.01 , P <0.05 ), and an increase of leptin, corticosteoid, insulin 24-48 h after birth ( P < 0.05 , P < 0.01 , P < 0.05 respectively). The increase of body weight at the 5th day after birth was decreased ( P < 0.05 ). At the 5th day after birth, the above hormones were close to the normal. Conclusion: The endocrine changes of the asphyxia newborns interfere with the growth and development.
出处
《中国康复》
2002年第2期94-95,97,共3页
Chinese Journal of Rehabilitation