摘要
观察了向侧脑室内注射雨蛙肤(1ng/鼠)对大鼠胃液分泌及胃液中前列腺素(PG)E_2含量的影响。实验结果表明:(1)侧脑室内注射雨蛙肽,明显地抑制大鼠胃酸的分泌,同时促进胃壁结合粘液的分泌,而对胃蛋白酶的活性则无明显影响;(2)雨蛙肽在中枢抑制胃酸分泌的作用,可被预先侧脑室内注射纳络酮所阻断,而雨蛙肽促进胃壁结合粘液分泌的作用则不受纳络酮影响;(3)侧脑室内注射雨蛙肽可明显增加胃液中PGE_2的含量。结果提示,雨蛙肽在中枢可能通过吗啡受体抑制胃酸分泌。雨蛙肽促进胃壁结合粘液分泌的作用则与吗啡受体关系不大。
The effect of in tracerebroventricular (ICV) injection of caerulein (1 ng/rat) on gastric juice secretion and content of PGE_2 in gastric juice was observed. Drugs were injected into the cerebroventricle in the rat of which the pylorus had been ligated. The gastric juice was collected for 5h and analyzed. The results were as follows. (1) ICV injection of caerulein significantly inhibited gastric acid secretion but stimulated gastric barrier mucus secretion and increased the content of PGE_2 in gastric juice; (2) Prior ICV administration of naloxone (5 μg/rat) abolished the inhibitory effects of caerulein on gastric acid secretion, but did not influence the secretion of the gastric barrier mucus. The results suggest that the inhibitory effect of caerulein on gastric acid secretion may be realized through central opiate receptors.
出处
《延边医学院学报》
1991年第1期5-8,共4页
Journal of Medical Science Yanbian University
关键词
雨蛙肽
胃液
前列腺素E
纳络酮
caerulein
intraventricular injection
gastric juice
prostaglandins E
naloxone
