摘要
目的 :调查兰州地区乙肝病毒基因分型情况及其和性别、血清标志物的关系。方法 :用PCR 微板核酸杂交 ELISA法对 88例兰州地区慢性无症状携带者 (AsC)及慢性乙型肝炎 (CHB)、肝炎后肝硬化 (HLC)的HBVDNA进行基因分型 ,并用酶免疫法 (EIA)测其血清标志物 (HBV M )。结果 :兰州地区基因型C型 67 0 % ,B型 12 5 % ,B、C混合型18 2 % ,其他型 2 3 %。男、女性感染HBVDNA构成比存在差异 ,HBeAg阳性率C型较B型高。结论 :兰州地区的基因型以C型为主 ,乙肝病毒基因亚型易感性可能存在性别差异 ,不同基因亚型感染可形成不同的血清标志物。
Purpose: To investigate the genotypes of HBV DNA infecton in Lanzhou China and relationships between genotype and sex, HBV M. Methods: We classified HBV DNA of 88 AsC? CHB? HLC living in Lanzhou by using PCR Microplate sandwith hybridization ELISA technique, whose HBV M were detected by EIA. Results: Among them, genotype C was 67.0%, genotype B 12.5%, mixed genotype B and C 18.2%, genotype A or D 2.3%. Proportion of genotypes between male and female was different. Positive rate for HBeAg of genotype C was higher than that of genotype B. Conclusion: Genotype C is the main genotype in Lanzhou. Susceptibility of HBV may have difference of sex. Infection of HBV of different genotype forms different HBV M.
出处
《临床消化病杂志》
2002年第3期99-100,共2页
Chinese Journal of Clinical Gastroenterology
