摘要
通过对110名HBV阴性儿童乙肝疫苗5年免疫效果(7月后87.27％;64个月后60.00％)和保护率(100％)的研究,进一步证实,国产乙肝疫苗不仅可用于一般人群,在高危人群和特殊地区同样具有良好的保护效果。但5年后应加强一针,以保持恒定的保护能力。影响HBV流行的因素不对抗-HBs应答产生作用。
A study on the immunogenicity protective efficacy of hepatitis B vaccine was carried out in 110 'healthy' children who were confirmed to be negative for all HBV sero-markers. A 5-year long-term observation showed that the anti-HBV sero-conversion rate and the efficacy rate in vaccinated group were 87.27% and 100% respectively. It is confirmed that the hepatitis B vaccine made in China is good not only in average-incidence areas, but in the high-incidence area of HBV. It is suggested that the children 5 years after vaccination should be given a booster dose of the vaccine to strengthen and maintain their immunogenicity to HBV. The prevalence factors of HB were also found to have no effect on the positive rate for anti-HBs conversion following vaccination.
出处
《徐州医学院学报》
CAS
1991年第4期235-237,共3页
Acta Academiae Medicinae Xuzhou
关键词
儿童
血源型
乙型肝炎
疫苗
hepatitis B vaccine
serological epidemiology
high-risk population
children
