摘要
为观察心脏围手术期甲状腺激素水平的变化并探讨其临床意义 ,对 2 0例心脏手术患者于手术前后各时间点取静脉血标本 ,利用放射免疫法测定甲状腺激素水平。结果发现 ,体外循环 (cardiopulmonarybypass ,CPB)期间以及术后血浆三碘甲状腺原氨酸 (T3 )、甲状腺素 (T4)及游离三碘甲状腺原氨酸 (FT3 )均明显降低 :T3 及T4在转流至最低体温时达到最低 ,术后 5天水平仍明显低于术前 ;促甲状腺激素 (TSH)及游离甲状腺素 (FT4)水平手术前后无明显变化。结论 :体外循环手术对甲状腺功能有严重影响 ,使患者处于低T3 综合征状态 ,而低T3
To observe the changes of perioperative serum thyroid hormone and their clinical significance, blood samples were obtaines from 20 patients before, during and after heart operations. Thyroid hormones were measured by radioimmunoassay. The results showed that serum T 3, T 4 and FT 3 levels significantly declined during cardiopulmonary bypass(CPB) and thereafter. Serum T 3 and T 4 concentrations reached their nadir at the lowest hypothermia of CPB. TSH and FT 4 levels remained normal ranges at postoperative sampling times. Conclusions: CPB would severely affect patients′ thyroid function, thus simulated a 'low T 3 syndrome', and low T 3 syndrome would produce side effects on postoperative heart function.
出处
《标记免疫分析与临床》
CAS
2002年第2期63-65,共3页
Labeled Immunoassays and Clinical Medicine
