摘要
目的 探讨甲状腺功能紊乱患者血清瘦素水平变化及瘦素与垂体—甲状腺轴 (PTA)的关系。方法 对 40例Graves病 (GD)、30例甲状腺机能减退症 (甲减 )患者和 2 8名健康受试者的血清瘦素 (leptin)、游离三碘甲状腺原氨酸 (FT3 )、游离甲状腺素 (FT4 )、促甲状腺激素 (TSH)、体脂百分含量 ( %BF)进行检测 ,所有受检者体重指数 (BMI) <2 5kg/m2 。结果 对照组血清瘦素浓度为 ( 5 .38± 3.11)ng/ml ,GD组为 ( 6 .0 7± 2 .93)ng/ml ,两组比较 ,差异无显著性 ,甲减组为 ( 10 .41± 4.45 )ng/ml,与对照组比较显著升高。三组血清瘦素浓度均与其 %BF显著正相关。对照组瘦素与TSH正相关 ,与FT3 、FT4 无相关关系。GD组瘦素与TSH、FT3 、FT4 无相关关系。甲减组因大多数TSH值增高超出检测范围 ,未作瘦素与之的相关性比较 ,而瘦素与FT3 、FT4 呈负相关关系。结论 甲状腺激素可能通过影响体脂含量而调节瘦素水平 ,瘦素和PTA是共同维持机体能量稳态的两个相互关联的系统。
Objective To investigate the relationship between serum leptin levels and pituitary thyroid axis (PTA) in patients with thyroid dysfunction. Methods The serum leptin, free triiodothyronine(FT 3),free thyroxine(FT 4),thyroid stimulating hormone (TSH) and body fat percentage (%BF) were measured in 28 normal subjects(control group),40 patients with Graves disease (GD) and 30 patients with hypothyroidism. The body mass index (BMI) of all the subjects were less than 25 kg/m 2. Results Serum leptin level in GD patients (6.07±2.93) ng/ml was not significantly different from that of control group (5.38±3.11 )ng/ml. Serum leptin level of hypothyroidism patients was higher than that in control group. Serum leptin level was correlated with %BF in three groups. In control group, serum leptin level was correlated with TSH , there was no correlation between leptin and FT 3?FT 4. In GD group, levels of leptin in serum weren't correlated with TSH?FT 3?FT 4. In hypothyroidism group, serum leptin levels were inversely correlated with FT 3?FT 4, the correlation between leptin and TSH wasn't observed because most TSH levels were above the detection limit. Conclusion Thyroid hormone may regulate leptin levels by influencing body fat percentage. Leptin and the PTA may represent two interacting systems for energy homestasis.
出处
《临床内科杂志》
CAS
北大核心
2002年第3期194-195,共2页
Journal of Clinical Internal Medicine
