摘要
研究目的探讨急性白血病(AL)患者抗凝血酶Ⅲ(AT-Ⅲ)活性的变化。研究设计检测22例AL患者和60例正常人AT-Ⅲ活性,并对测定结果进行统计学处理。研究单位一附院血液病研究室患者及主要参与者 AL患者22例,男性13例,女性9例,年龄19～58岁,所有病例均符合1986年天津会议诊断分型标准。对照组60例,男性30例,女性30例,均为我院输血队员,年龄19～45岁。处理方法对22例AL患者和60例正常人抽静脉血,用凝血酶凝胶空斑法测定血清AT—Ⅲ活性,对测定结果进行t检验。测定结果 22例AL患者和60例正常人AT-Ⅲ活性分别是114.58±81.28％和94.58±28.56％。两组比较有显著性差异(t=7.55,P<0.01)。结论 AT—Ⅲ活性增高是AL患者出血原因之一。
Study Objective To scarch Antithrombin Ⅲ(AT-Ⅲ) in partients with acute leukemia (AL). Design The scrum AT-Ⅲ activity in 22 patients and 60 normal persons were determined, and the statistical trcatment of determination results was carried out. Setting Rescarch Laboratory of Haematology, the First A ffiliated Hospital. Patients and Other Participants In 22patients with acute leukemia, the range of age is was 19 to 58 years old. All the symptoms, singns and laboratory findings are according with diagostic criterion of acute leukemia. All the 60 normal control are blood donor, the range of age was from 19 50 45 years old. Intervention The venous blood of 22 patiens with acute leukemia and 40 normal persons were drown. The serum levels of AT—Ⅲ was determined by thrombin gel empty zone, The t test was performed in the results of measurement. Mensurement and Results The serum AT-Ⅲ levels of 22 cases of AL and 60 noemal persons are 114.5±81.28% and 94.58±28.56% respectively (t=7.55, P<0.01). There is an obvious different between patients with acute leukemia and 60 normal persons. Conclusion Activity increased of AT-Ⅲ is one of the reasons of the heamorrhage of patients with AL.
出处
《新乡医学院学报》
CAS
1991年第4期268-269,共2页
Journal of Xinxiang Medical University
关键词
抗凝血酶Ⅲ
白血病
acute leukemia
AT—Ⅲ activity
plaque technique
