摘要
目的 :探讨胎膜早破孕妇血和羊水中白细胞介素 6 (IL- 6 )、白细胞介素 8(IL- 8)水平与绒毛膜羊膜炎关系。方法 :采用酶联免疫吸附法 (EL ISA)检测 5 8例胎膜早破 (受试组 )及 4 0例正常孕妇 (对照组 )血清和羊水中 IL- 6、IL- 8水平 ,同时行胎膜病检。结果 :胎膜早破组患绒毛膜羊膜炎 33例 ,感染率为 5 5 .17% ,明显高于对照组 (15 .0 0 % )。绒毛膜羊膜炎孕妇的羊水和血清中 IL- 6、IL- 8水平明显高于非绒毛膜羊膜炎者 ,尤其以羊水中 IL- 6、IL- 8水平升高更为敏感 (P <0 .0 1)。胎膜早破时间长短与绒毛膜羊膜炎发生率呈正比 ,当破膜时间超过 2 4 h,则绒毛膜羊膜炎发生率为 77.78% ,当破膜时间在 12～ 2 3h为 5 0 % ,破膜时间在 12 h内为 30 % ,而对照组绒毛膜羊膜炎发生率只为 15 .38%。结论 :羊水和血清中 IL- 6、IL- 8水平升高与绒毛膜羊膜炎有关 ,胎膜早破时间越长 ,发生率越高。
Objective: To study the change and clinical significance of maternal serum and amniotic fluid interleukins 6 and 8 (IL 6 IL 8) levels in patients with chorioamnhionitis and premature rupture of membrane (PROM) Methods: Forty normal term pregnant women as control, and fifty eight women with PROM were included in study group Maternal serum and amniotic fluid IL 6 and IL 8 levels were measured by enzyme labeled immunosorbent assay (ELISA) Chorioamnionitis was diagnosed histologically Results: There were 33 (55 17%) cases with chorioamnionitis in patients with PROM and were higher than that of normal term pregnant women (15 0%) The IL 6 and IL 8 levels in maternal serum and amniotic fluid were higher in patients with chorioamnionitis than that of non chorioamnionitis (P<0 01) The longer was the time, the higher were the chorioamnionitis Conclusion: IL 6 and IL 8 in maternal serum and amniotic fluid are valuable clinical indices for identification of chorioamnionitis in patients with PROM
出处
《广西医科大学学报》
CAS
2002年第2期184-186,共3页
Journal of Guangxi Medical University
基金
广西自然科学基金资助项目 (桂科自 0 0 43 0 0 3 )
