摘要
目的 :比较咪唑斯汀与西替利嗪、特非那定、氯雷他定治疗急性荨麻疹的临床疗效。方法 :急性荨麻疹患者 13 8例随机分为 4组 ,第 1组 3 7例 ,给予咪唑斯汀 10mg ,po ,qd ;第 2组 3 2例 ,给予西替利嗪 10mg ,po ,qd ;第 3组 3 5例给予特非那定 60mg ,po ,bid ;第 4组 3 4例给予氯雷他定 10mg ,po ,qd。在服药前和服药后的第 1,3 ,6,2 4小时对患者瘙痒程度、风团大小及数量进行评分 ,依此评价疗效。结果 :咪唑斯汀组 1h起效 ,明显快于其他三组 (P <0 .0 5 ) ;3 ,6h疗效与西替利嗪 ,特非那定相当 (P >0 .0 5 ) ,优于氯雷他定 (P <0 .0 5 ) ;2 4h维持效果与特非那定 ,氯雷他定相当 (P >0 .0 5 ) ,优于西替利嗪 (P <0 .0 5 )。结论 :咪唑斯汀治疗急性荨麻疹起效快 ,维持时间长 。
Objective:To compare the clinical efficacy of mizolastine (M) and cetirizine (C), terfenadine (T), loratadine (L) in the treatment of acute urticaria. Methods:Volunteers were divided into the following groups: group M (10 mg, po, qd, 37 subjects), group C (10 mg, po, qd, 35 subjects), group T (60 mg, po, bid, 34 subjects), group L (10 mg, po, qd, 34 subjects). The efficacy was evaluated at one hour, three and six hours, twenty four hours after oral intake of the various drugs. Results:The effect was quicker and stronger in group M than that in groups C, T and L( P <0.05) after 1 hour. The effect was similar in groups M, C and T after 3 and 6 hours ( P >0.05), but all stronger than group L ( P <0.05). The effect was similar in groups M, T and L after 24 hours ( P >0.05), but all stronger than group C ( P <0.05). Conclusion:Misolastine is a quick acting and ultralente drug for acute urticaria. It is worthwhile to be used clinically.
出处
《医药导报》
CAS
2002年第6期348-349,共2页
Herald of Medicine
