摘要
0 前言硝基苯乙酸是重要的医药和有机合成中间体,其经典合成方法常由于原料难得或使用毒性大的腈化物,给工业生产带来困难。G.Bottaccio等报道了对硝基甲苯在酚钠的存在下能和CO_2发生羧基化反应,得对硝基苯乙酸.
An improvement on carboxylation agent to synthesizenitrophenylacetic acids has been worked out, in which sodium carbonates(or potassium carbonate) is used as a part of carboxylation agent. whenmole ratio-sodium phenolate: nitrotoluene(o-or p-) :sodium sarbonate(or potassium carbonate) attains 2:1:0.5, o-nitrophenylacetic acid yieldsin 82%, and p-nitrophenylacetic acid in 90%, if adding a little of tetra-butyl ammonium bromide at the same time.
出处
《湘潭大学自然科学学报》
CAS
CSCD
1991年第3期66-69,共4页
Natural Science Journal of Xiangtan University
基金
国家自然科学基金
关键词
羧化剂
硝基甲苯
硝基苯乙酸
合成
nitrotoluene
nitrophenylacetic acid
synthesize
carbonate
sodium phenolate
