摘要
研究了大鼠脑缺血 45分钟再灌注 3天后血清及脑组织MDA、SOD、NO及NOS的变化及补阳还五汤的保护作用。结果缺血再灌注后大鼠血清及脑组织MDA和NO含量显著升高 ;脑组织SOD活性显著降低 ;NOS活力显著升高 ,补阳还五汤能有效的防止这些变化。
Objective: To study the changes of MDA, SOD, NO and NOS in serum and brain tissue after cerebral ischemia and reperfusion in rats and the protective effect of Buyanghuanwutang (BYHWT). [WT5”HZ]Method:[WT5”BZ] By ligating bilateral carotid for 45 min followed reperfusion 3 days in rats, the level of MDA and NO in serum and brain tissue and the activity of SOD and NOS in brain tissue were measured. [WT5”HZ]Result:[WT5”BZ] After cerebral ischemia reperfusion, the concentration of MDA and NO in serum and brain tissue was significantly increased; the activity of SOD was significantly decreased; and the activity of NOS was significantly increased. BYHWT could effectively prevent these changes. [WT5”HZ]Conclusion:[WT5”BZ] BYHWT may play the role of antagonizing cerebral ischemia reperfusion injury by raising antioxidation of the brain tissue and reducing the content of NO and the activity of NOS.
出处
《中药药理与临床》
CAS
CSCD
2001年第2期3-4,共2页
Pharmacology and Clinics of Chinese Materia Medica
基金
山东省自然科学基金课题!Y98C0 1 0 30
