摘要
观察了重组白细胞介素-2（IL-2）对健康成年猪和PRRS抗体阳性猪的猪瘟疫苗免疫效果的影响。结果显示,重组IL-2和猪瘟疫苗一起免疫健康猪,20d后间接血凝抗体滴度达到1∶64的猪的比例为87.5％,而不注射IL-2的对照组抗体滴度可以达到这一水平的比例只有25％。给经2次猪瘟疫苗免疫但抗体滴度在1∶32以下的PRRS抗体阳性猪单独注射IL-2,20d后,注射前检测不到抗体的猪都检测到了抗体,注射前抗体滴度在1∶8～1∶16之间的猪的抗体滴度提高到1∶32～1∶64。再次用猪瘟疫苗和IL-2共同免疫,可使抗体滴度提高4倍以上。而不注射的对照组抗体滴度则略有下降。说明重组IL-2可以减轻PRRS感染所引起的免疫抑制,提高猪瘟疫苗的免疫效果。
The effects of recombinant IL-2 on the antibody levels against swine fever virus in the healthy and PRRS antibody positive pigs were studied . The rate of pigs with antibody litres 1:64 immunized with attenuted swine fever vaccine and IL-2 20 days after immunization increased to 85 % in comparison with that of 25% in control animals immunized only with vaccine when tested with indirect heamagglutination assay. In the pigs with PRRS antibody positive and the antibody tilers to swine fever virus lower than 1∶32 after immunization for 2 times using attenuated swine fever vaccine , the injection of IL-2 could only induce the pigs from antibody negative to antibody positive, from the antibody titre 1∶8-1∶16 to 1∶32-1∶64. The results indicated that the recombinant IL-2 could relieve pigs from immunosuppression of PRRS and enhance the immune effects of swine fever vaccine.
出处
《畜牧与兽医》
北大核心
2002年第5期9-11,共3页
Animal Husbandry & Veterinary Medicine
