摘要
目的 探讨以 2 18氟 2 去氧 D 葡萄糖 (18FDG)为示踪剂的正电子发射断层照相术 (PET)在卵巢上皮性癌术后病情监测中应用的效果。方法 经满意的肿瘤细胞减灭术和术后 6～ 9个疗程化学药物治疗后 ,临床上完全缓解 6个月以上的卵巢上皮性癌患者 13例 ,在随访过程中 ,进行了 15人次 (13例 )的PET检查 ,及 10人次 (9例 )的二次探查手术或再次肿瘤细胞减灭术。并将PET检查与手术病理检查及同期的CA12 5、B超、CT等检查进行了对照研究。结果 8例 (9人次 )PET检查提示的2 1处盆腹腔内异常高代谢病灶经病理检查证实全部为卵巢上皮性癌复发灶 ,阳性预测值为 10 0 %。而同期CA12 5水平异常升高的 8例 (9人次 )患者中 ,盆腹腔B超、CT检查发现占位病灶各 1人次 ;PET检查发现了多个B超及CT检查漏诊的 0 5～ 1 5cm的微小癌灶。在PET检查阴性的 6例患者中 ,1例进行了二次探查术 ,盆腹腔多点活组织检查未发现转移癌 ;5例未手术患者中 ,4例严密随访 11～ 13个月未发现复发征象 ,1例于第 9个月出现CA12 5水平升高 ,复查PET出现阳性病灶 ,并经手术病理检查证实为卵巢上皮性癌复发 (该例已包括在上述 8例中 )。结论 在卵巢上皮性癌的术后病情监测中 ,PET检查作为一种无创检查手段 ,成像清晰、定位准确 ,可能成为早?
Objective To investigate the efficiency of positron emission tomography (PET) with (fluorine 18) 2 deoxyglucose( 18 FDG)for detecting recurrent epithelial ovarian carcinoma Methods Fifteen 18 FDG PET scanning were performed on 13 patients, who was clinically free of disease after optimal cytoreductive surgery and sufficient chemotherapy, with suspicion of recurrence Ten second look or re debulking operation were given after PET scanning Results In all 8 cases with and 1 without elevated serum CA 125 , PET demonstrated sites of increased 18 FDG uptake, which correlated well with surgical pathologic findings (100%) Computed tomography scan and B ultrasonography each detected 1 recurrence One of the 6 patients with negative PET scan results underwent a second look operation, which found no malignancy The other 5 were closely followed up for 11 to 13 months No sign of recurrence was noticed within 8 months One patient received her second PET scanning after the serum CA 125 began to elevate in the 9th month Recurrent tumor was found by the second PET scan and confirmed by the operation after that Conclusions PET is accurate in detecting the recurrent epithelial ovarian carcinoma As a non invasive method, PET might be a fairly effective tool for monitoring and locating the recurrence of ovarian carcinoma
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2002年第6期356-358,共3页
Chinese Journal of Obstetrics and Gynecology
