摘要
目的 观察比较骨膦 (BONEFOS ,氯甲膦酸二钠 )、博宁 (BONIN ,帕米膦酸二钠 )、阿可达 (AREDIA ,帕米膦酸二钠 )对治疗恶性肿瘤骨转移骨痛的止痛效果 ,活动能力改善、血清钙、磷含量变化。方法 临床确诊的恶性肿瘤骨转移病人 6 5例 ,随机分组。骨膦组 :30 0mg静注 ,每日一次 ,连用 5天 ,继而口服骨膦胶囊 ,80 0mg ,一日三次 ,连用 15日 ;博宁组 :6 0mg～ 90mg静滴 ,一次使用 ;阿克达组 :6 0mg～ 90mg静滴 ,一次使用 ;三者均以四周为一个治疗周期 ,四周后可重复使用。结果 控制骨痛有效率骨膦 40 .0 % ,博宁 5 7.7% ,阿可达 84.2 % ,治疗前后及组间比较均具有显著性差异 (P <0 .0 5 ) ;疼痛分级比较 ,阿可达在控制剧烈骨痛方面 ,即Ⅱ级 ,Ⅲ级骨痛 ,疗效明显优于应用骨膦、博宁组 ,差异显著 (P <0 .0 5 ) ;活动能力骨膦组有效率为 45 % ,博宁 6 1.5 % ,阿可达 84.2 % ,组间比较差异显著 (P <0 .0 5 ) ,阿可达有效率中显效病例占有较高的比例 ,而其它两组中有效病例为构成有效率的主要部分 ,具有显著性差异 (P <0 .0 5 ) ;三组中血钙均明显下降 ,前后差异显著 (P <0 .0 5 ) ,组间未见显著性差异 (P >0 .0 5 )。血磷在治疗前后未见明显改变。结论 阿可达能有效地控制骨转移性癌痛 ,改善活动能力 。
Objective To observe the acesodyne effect,mobility and the change of serum calcium and phosphorus on metastatic carcinoma of bone treated by Bonefos,Bonin and Aredia.Methods 65 cases were randomized into Bonefos group:300mg Qd ivdrop,d1-d5,800mg tid po d6-d20;Bonin group:60mg～90mg ivdrop;Aredia group:60mg～90mg ivdrop.4 weeks were as a course.Results The effective rate of acesodyne effect in Bonefos,Bonin and Aredia group were 40.4%,57.7% and 84.2%,respectively,showing a significant difference (P<0.05).Acesodyne effect in Aredia group was better than that in Bonefos and Bonin groups for Ⅱ° and Ⅲ° ache of bone(P<0.05).The effective rates for mobility were 45%,61.5% and 84.2% in Bonefos,Bonin and Aredia group (P<0.05) respectively.And the level of acesodynes effect in Aredia group was better than those in the other two groups (P<0.05).The serum calcium debased evidently after the treatment in the three groups(P<0.05).There was no significent difference in the groups(P>0.05).The serum phosphorus had no change after the treatment.Conclusion Aredia has a significent curative effect on metastatic carcinoma of bone.
出处
《中国肿瘤临床与康复》
2002年第3期101-102,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
双膦酸盐
肿瘤
骨转移
止痛
治疗
bisphosphonates
metastatic Carcinoma/bone
acesodyne effect
