摘要
目的:用统计参数地图(statisticalparametricmapping,SPM)软件包分析焦虑症患者局部脑血流(regionalcerebralbloodflow,rCBF)灌注的变化。方法:选择经CCMD-2或ICD-10诊断为焦虑症患者19例,进行脑99mTc-ECD显像,并与23例年龄匹配的健康人作比较。用SPM软件包对脑血流图像进行组间比较,分析焦虑症患者大脑血流变化情况。结果:焦虑症患者的局部脑血流双侧颞叶、额上回、扣带回明显降低。而在中央前回、额叶眶部、左基底节血流明显升高。结论:焦虑症患者的局部脑血流有明显的变化,且与其发病机理相关。
Objective:To analyze the regional cerebral blood flow(rCBF) alternations in patients with anxiety disorder,comparing with normal subjects using statistical parametric mapping.Methods:99mTc ECD-brain SPECT imaging were performed in 19 anxiety disorder patients(ADP) diagnosed with CCMD 2 or ICD 10,and 23 cases with age matched normal controls for comparison.Situation of rCBF in ADP was analyzed by SPM method under the condition of increased and decreased perfusion.Results:The rCBF of bilateral temporal,superior frontal gyrus and callosal gyrus were significantly decreased in the anxiety group,and the rCBF of precentral gyrus,frontal lobe orbital part,left basal ganglia was significantly increased(P<0 05).Conclusion:SPM analysis showed that significant rCBF change in anxiety disorder patients and related to disease pathophysiology.
出处
《中国临床医学影像杂志》
CAS
2002年第2期77-79,共3页
Journal of China Clinic Medical Imaging
关键词
焦虑症
体层摄影术
发射型计算机
单光子
anxiety disorders
tomography,emission computed,single photon
