摘要
目的 探讨肾移植术后乙型肝炎病毒相关性纤维化淤胆性肝炎的临床及组织学特征。方法 回顾观察了 3例肾移植术后乙型肝炎病毒相关性纤维化淤胆性肝炎患者的临床特点 ,并对其肝穿刺组织进行HE、浸银染色及乙型肝炎病毒核心抗原 (HBcAg)免疫组织化学染色观察。 结果 3例患者均表现为进行性肝功能衰竭 ,血清转氨酶仅轻度上升 ;汇管区广泛纤维化 ,毛细胆管及肝细胞内胆汁淤积明显 ,炎性细胞浸润轻 ,肝细胞乙型肝炎病毒核心抗原 (HBcAg)强表达。 结论 肾移植术后的乙型肝炎病毒相关性纤维化淤胆性肝炎是一种特殊的、致死性病毒性肝炎 ;
Objective To study the clinical and histological characteristics of fibrosing cholestatic hepatitis (FCH) associated with HBV following renal transplantation.Methods A retrospective review of clinical manifestation was carried out in 3 patients with FCH associated with HBV following renal transplantation. The biopsied liver specimens were studied with HE staining, silver staining and immunohistochemistry staining.Results All the 3 patients showed progressive hepatic failure, a mildly increased serum aminotransferase level, extensive periportal fibrosis, intense canalicular and cellular cholestasis, mild inflammatory infiltration, and strong expression of B viral antigens in the hepatocytes.Conclusion FCH asso ciated with HBV following renal transplantation is a special and fatal form of viral hepatitis. It is necessary for the asymptomatic HBsAg carriers following renal transplantation to monitor the liver function.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2002年第3期149-151,I001,共4页
Chinese Journal of Organ Transplantation
