摘要
目的 探讨在 2型糖尿病大鼠模型中胰岛素敏感指数 (ISI)的影响因素及优化复合纤维(SFC)对该模型ISI和血脂的影响。方法 将Wistar雄性大鼠 2 6只 ,用小剂量链脲霉素 +高糖、高脂饲料处理 10周诱导形成 2型糖尿病大鼠模型。进行糖耐量试验 (GTT)、测定空腹胰岛素 (FINS)、胆固醇 (TC)、甘油三酯 (TG) ,并计算糖耐量曲线下面积 (AUC)和ISI。以 7只正常大鼠做对照。用多因素逐步回归分析 ,探讨影响ISI的主要因素 ,并比较糖尿病大鼠用优化的复合纤维 (SFC)治疗 8周前后的效果。结果 模型组与对照组比较AUC增大 ,FINS、TC、TG增高 ,ISI降低。TG和AUC是影响糖尿病大鼠ISI的主要因素。SFC可降低TC和TG ,减少AUC和提高ISI。结论 本实验所建立的 2型糖尿病大鼠模型中高TG血症和糖耐量异常是影响ISI的主要因素。SFC对降低高血脂、改善糖耐量、提高ISI有重要意义。
Objective To explore the factors affected insulin sensitivity index (ISI) and the effects of superior fiber complex (SFC)on ISI and blood lipids in non insulin dependent diabetes mellitus (NIDDM) rats.Methods Twenty six male Wistar rats were injected with low dose of streptozotocin and fed a diet with high calorie and high fat for ten weeks and glucose tolerance (GTT),fasting insulin (FINS),total cholesterol(TC) and triglyceride(TG) were measured while area under curve(AUC) and insulin sensitivity index (ISI) were also calculated. The results were compared with those from 7 normal control rats. Multi factor regression analysis was used to analyze those factors affected ISI. In the same experiment,13 rats with diabetes mellitus were treated with Superior Fiber Complex (SFC)for 8 weeks and the results were compared with the pre treated data.Results Compared with the control group,AUC in the diabetic group was larger,and FINS, TC and TG were higher; but ISI was lower. Therefore, The TG and AUC was the major factor affected ISI. TC and TG were lowered and AUC was reduced and ISI increased.Conclusion High TG and impaired glucose tolerance (IGT) are main risk factors of ISI in the rat model, and SFC could increase ISI, decrease high blood lipids and prevent IGT.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2002年第3期184-186,共3页
Chinese Journal of Preventive Medicine
基金
山西省归国留学人员基金资助 (9760 )
关键词
优化复合纤维
糖尿病
胰岛素敏感指数
血脂
非胰岛依赖型
血糖
动物实验
Diabetes mellitus, non insulin dependent
Diabetes millitus, experimental
Insulin resistance
Blood glucose
Lipids
