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leptin与多囊卵巢综合征 被引量:8

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摘要 瘦素(leptin)与多囊卵巢综合征(PCOS)的关系及leptin在生殖中的作用引人注目。测定血清、卵泡液、脑脊液中leptin水平及全身各脏器leptin受体mRNA的表达提示。PCOS妇女leptin水平增高,肥胖PCOS者增加尤甚,体重指数(BMI)是最根本的决定因素。卵巢、子宫、脂肪组织、下丘脑等组织均有leptin受体,leptin不仅可以通过外周循环作用于下丘脑-垂体-卵巢轴,也可通过卵泡液直接作用于卵巢。leptin可影响PCOS妇女的体重、神经内分泌、卵巢功能和生育功能。而PCOS也可调节leptin的合成、分泌及其功能效应。
出处 《国外医学(妇产科学分册)》 2002年第2期82-85,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
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