摘要
用椰毒假单胞菌产生的毒黄素注入小鼠腹腔引起急性中毒,约2h动物处于濒死状态。取脏器和血液以丙二醛法测定其脂质过氧化作用。显示肾和脑组织呈明显的脂质过氧化,而心脏、肺和血液未看到此种作用。考虑到毒黄素是作为还原性辅酶Ⅰ或FMNH_2与氧之间的电子传递体而产生H_2O_2的,因而推测产生H_2O_2的部位在线粒体和细胞浆,使线粒体受到损伤并影响糖酵解。
Toxoflavin produced by pseudomonas cocovenenans was injected abdominally into mice to induce acute poisoning. The mice were in imminent death state almost two hours after the injection. Internal organs and blood were taken to ketermine lipid peroxidation by malondialdehyde method. Tissues of kidney and brain showed lipid peroxidation significantly whereas heart, lung and blood were no change in this respect. Considering toxoflavin acts as an electron carrier between DPNH or FMNH_2 and oxygen producing H_2O_2, we suppose that the site of production of H_2O_2 by toxoflavin probably be mitochondria and cellular plasma resulting in decrease of ATP production, lipid peroxidation is not the principal cause of toxicity of toxoflavin.
出处
《潍坊医学院学报》
1991年第1期23-25,共3页
Acta Academiae Medicinae Weifang
关键词
毒黄素
椰毒假单胞菌
脂质过氧化
toxoflavin
pseudomonas cocovenenans
lipid peroxidation
active oxygen
