摘要
目的 研究CD4 4v6在不同组织学类型的胃癌和混合型组织学类型胃癌中表达与侵袭和转移的关系。方法 4 0例经外科手术切除的胃癌石蜡包埋组织 ,选用CD4 4v6单克隆抗体 ,采用sABC法 ,进行免疫组织化学检测。结果 中分化腺癌常伴有粘液腺癌 ;低分化腺癌多伴有印戒细胞癌。CD4 4v6在中分化腺癌伴粘液腺癌组织中的表达率为 33 3% ;而在低分化腺癌伴印戒细胞癌组织中的表达率为 6 6 7%。结论 低分化腺癌伴有印戒细胞癌中CD4 4v6的高表达率可能说明在侵袭和转移方面高于中分化腺癌伴有的粘液腺癌。
Objective To investigate the relationship between expression and invasive-metastasis of gastric carcinoma of differential and mixed histologic type of CD44v6. Methods 40 cases paraffin-embedded tissue of gastric carcinoma through surgical operation were studied. Immunohistochemical SABC method was performed by using monoclonal antibody of CD44v6. Results Moderate differentiated adenocarcinoma of stomach usually accompanied by mucous adenocarcinoma; poorly differentiated adenocarcinoma of stomach usually accompanied by signet-ring cell carcinoma, and the positive rates of CD44v6 were 33.3% and 66.7% respectively. Conclusion The results suggested that the CD44v6 overexpression in the later was higher than that in former on invasive metastasis.
出处
《黑龙江医学》
2002年第5期326-327,共2页
Heilongjiang Medical Journal
