摘要
目的研究我国西北地区风湿性心脏瓣膜病人机械瓣膜置换术后行低强度抗凝的可行性及合理的抗凝强度。方法将本地区50例患者按国际标准化比值(INR)随机分为3组并于术后定时分别测其凝血酶原时间(PT)及相应的INR、D-二聚体浓度、抗凝血酶Ⅲ活度(AT-Ⅲ:C),并监测其术后出血及血栓形成的发生率。结果机械瓣膜置换术后,INR控制于1.3～1.7范围内即可保持D-二聚体浓度、AT-Ⅲ:C与对照组无显著性差异(P>0.05),3组术后并未出现血栓形成。结论西北地区风湿性心脏瓣膜患者机械瓣膜置换术后行低强度抗凝是可行的,术后采取INR控制于1.3～1.7的低强度抗凝是安全的。
Objective To evaluate the safety of the low dose oral anticoagulation therapy following heart valve replacement (HVR)in northwest China and research the optimal level of the therapy.Methods Fifty patients of northwest China received oral warfarin anticoagulation after HVR for at least6months.Each patient's blood sample was took for detection of PT,INR,D-dimer and AT-Ⅲ:C.Results In the group A,whose INR kept between1.3～1.7,D-dimer and AT-Ⅲ:C value were as same as the value of the control group(P>0.05).In the group A and C,whose INR kept between1.3～1.7and1.7～2.0,AT-Ⅲ:C value were slightly higher than group C,but not significant,while the rate of bleeding accidents were significantly higher than group A.No thrombolic accident was reported in each group.Conclu-sion A low intense anticoagulation with the INR between1.3～1.7is safe for the patients who received oral warfarin anticoagulation after HVR in northwest China
出处
《实用医药杂志》
2002年第5期335-337,共3页
Practical Journal of Medicine & Pharmacy
关键词
机械瓣膜置换
低强度抗凝治疗
西北地区
Mechanical heart valve replacement Low intense anticoagulation Northwest China
