摘要
目的 研究阿尔茨海默病 (AD)的功能性和结构性脑影像学特征。方法 将入组的 6 6例AD患者 (AD组 )和 73名健康老年人 (对照组 )分别按年龄分成 3组 :6 0～ 6 5岁组 ,6 6～ 70岁组 ,>70岁组。使用单光子发射计算机体层摄影术 (SPECT)和磁共振 (MRI)对AD组和对照组进行功能性和结构性脑显像检测。AD组和对照组中完成SPECT检查者分别为 6 0例和 73名 ;完成MRI者分别为 2 2例和 2 9名。结果 (1)AD组左颞叶 (F =5 19)、右颞叶 (F =4 14 )、左顶叶 (F =17 10 )、右顶叶 (F =2 0 10 )、左额叶 (F =12 4 0 )、右额叶 (F =11 70 )额叶的血流灌注量低于对照组 ,差异有显著或非常显著性 (P <0 0 5～ 0 0 1)。 (2 )AD组的 3个年龄组间的SPECT指标差异无显著性。 (3)在 6 0～ 6 5岁组和 >70岁组 ,AD和对照组的差异主要在双侧顶叶和额叶 (6 0～ 6 5岁组 :左顶叶t =3 85 ,右顶叶t=3 75 ,左额叶t=3 4 9,右额叶t=2 74 ;>70岁组 :左顶叶t=3 6 1,右顶叶t=3 4 5 ,左额叶t=3 90 ,右额叶t=4 12 ) ,差异有显著或非常显著性 (P <0 0 5～ 0 0 1)。 (4)AD组灰质体积 (F =34 4 0 )、左海马体积 (F =11 4 0 )、右海马体积 (F =2 1 6 0 )低于对照组 ,差异有非常显著性 (P <0 0 1) ;总脑脊液 (F =30 2 0 )、脑室外脑脊?
Objective To investigate the characteristics of functional and structural brain changes in Alzheimer′s disease (AD) Methods Sixty six AD patients and 73 health aged were recruited The subjects were divided into 3 age groups: 60-65 years, 66-70 years and over 70 years SPECT and MRI were conducted o the subjects with consent Radioactive Ratio (RAR) of SPECT was measured Results (1) The RARs of AD in bilateral temporal lobes, parietal lobes and frontal lobes were significantly lower than those of healthy aged ( P <0 05-0 01) (2) No significant perfusion differences between three AD age groups were found (3) AD patients in group aged below 65 years and over 70 years showed decreased blood flow in bilateral parietal and frontal lobes compared with healthy controls in the corresponding age group, respectively ( P <0 05-0 01) (4) Volumes of gray matter and bilateral hippocampi were significantly lower in AD than in healthy ( P <0 01), while volumes of total CSF, peripheral CSF, lateral ventricles, third and fourth ventricles were significantly higher in AD than in healthy (5) There were no significant structure differences between the three AD groups (6) AD showed decreased volumes of gray matter and right hippocampal, increased volume of total CSF, peripheral CSF, third ventricle compared with healthy in the corresponding age group (7) With left and right parietal RAR as variables, hierarchical cluster analysis was applied and 60 AD patients who completed SPECT were satisfactorily subdivided into 3 groups with mild, moderate or severe cognitive impairment according to their Mini Mental State Examination scores (8) Correlation analysis demonstrated that left and right hippocampus volumes were correlated to RARs of cingulate, bilateral parietal lobes, thalami, occipital lobes and basal ganglia Conclusions The pathological changes of AD are characterized with more affected areas and severity The correlation between volumes of bilateral hippocampi and perfusion of parietal l
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2002年第2期82-86,共5页
Chinese Journal of Psychiatry
基金
上海市医学领先专业老年重点学科建设基金项目 (沪卫 95Ⅲ011)
卫生部科研基金项目 (98 1 3 2 0 )
上海市卫生系统百人计划项目 (98BR0 0 3 )
关键词
阿尔茨海默病
脑单光子
体层摄影术
磁共振显像
Alzheimer Disease
Brain
Tomography, emission computed, single photon
Nuclear magnetic resonance
