摘要
目的探讨检测腺苷脱氨酶及多项肿瘤标志物对腹水性质的鉴别价值。方法将70例诊断明确由不同病因引起的腹水分为恶性、结核性及非结核良性3组,同步检测腺苷脱氨酶(ADA)、铁蛋白(FA)、癌胚抗原(CEA)、糖抗原19-9(CA19-9)及糖抗原50(CA50)含量。结果恶性腹水FA、CEA、CA19-9和CA50明显高于结核性及非结核性腹水,P<0.01。诊断恶性腹水的敏感性分别为73.9%、61.5%、69.2%及73.1%,特异性分别为93.5%、90.9%、91.4%及93.2%。4项联合检测的敏感性为95.1%,特异性为97.1%。结核性腹水ADA明显高于恶性及非结核良性腹水,P<0.01,ADA对结核性腹水诊断的敏感性为91.3%,特异性95.7%。结论联合检测腹水中FA、CEA、CA19-9、CA50及ADA,对恶性腹水及结核性腹水的鉴别诊断有重要临床价值。
Objective To explore the value for measuring the levels of ADA and many tumor markers in the differential diagnosis of ascites. Methods 70 cases with ascites caused by different reason were divided into three group ie, malignant ascites, tuberculous ascites and non tuberculous ascites. The levels of ADA, FA, CEA, CA19-9 and CA50 were detected. Results The levels of FA, CEA, CA19-9 and CA50 in malignant ascites were significantly higher than those in tuberculous and non tuberculous ascites(P<0.01). The diagnostic sensitivity rates of malignant ascites were 73.9%, 61.5%, 69.2%, and 73.1% respectively, and the specificity rates were 93.5%, 90.9%, 91.4% and 93.2% respectively, the total sensitivity and specificity rates of these four items were 95.1%, 97.1% respectively. The level of ADA in tuberculous ascites was significantly higher than those in malignant and non tuberculous ascites(P<0.01), and the diagnostic sensitivity rate of tuberculous ascites was 91.3%, specificity rate was 95.7%. Conclusion The examination of ascites FA, CEA, CA19-9, CA50 and ADA can be of great clinical value in the differential diagnosis of malignant and tuberculous ascites.
出处
《中国航天医药杂志》
2002年第2期27-29,共3页
Medical Journal of CASE
