摘要
一、前言东莨菪碱(Scopolamine)是一种麻醉药物,它是中草药曼陀罗花的主要成份。氚标记东莨菪碱是用于动物组织中的吸收,分布和代谢的研究。
Scopolamine is an important anaesthetic. ~3H-scopolamine was prepared by Wilzbach tritium gas-exposure method for the study of its pharmacokneties. The total radioactivity of ~3H-scopolamine was 61.8 MBq, radiochemical purity was 97%,and specific activity was 3.9 MBq/ mg. The location of ~3H-labelling was studied by calculating the superdelocalizability S_r(E) by CNDO/2 method. The calculated results agreed with experimental values by chemical dissociation method. The calculations showed that ~3H of tropic acid is 72% that of ~3H-scopolamine. As can be seen, the location of ~3H-labelling is mainly on the tropic acid.
出处
《同位素》
CAS
北大核心
1991年第4期221-225,共5页
Journal of Isotopes
关键词
氚气曝射
东莨菪碱
氚
标记
tritium gas-exposure, scopolamine,location of ~3H-labelling, superdelocalizability.
