摘要
用改良火箭免疫电泳法检测血清 FN,正常人血清 FN 含量为205±55mg/L;甲亢患者治疗前为521±341mg/L,升高非常显著(P<0.01),治疗后为196±62mg/L(P>0.05);甲减患者为142±103mg/L,降低非常显著(P<0.01),单纯性甲状腺肿、桥本氏甲状腺炎、甲状腺瘤、亚急性甲状腺炎患者分别为200±54mg/L、360±300mg/L、271±204mg/L、213±24mg/L(P>0.05)。血清 FN 与血清T_3、T_4呈正相关,提示血清 FN 的合成、分泌和代谢受甲状腺激素的影响;血清 FN 可作为甲亢、甲减疗效参考指标,在疾病的鉴别上也有参考价值。
Human serum fibronectin(SFN)was detected by improved rocket immunoelectro-phoresis assay.SFN level was 205±55mg/L((?)±SD)in healthy subjects.SFN level(521±341mg/L)of untreated hyperthyroidism patients was greatly increased(P<0.01).The protein level of treated hyperthyroidism patients was 296±62mg/L(P>0.05).SFN level(142±103mg/L)in hypothyroidism patients was greatly decreased(P<0.01);however,SFN levels of patients with simple goiter,Hashimoto's thyroidi-tis,thyrophyma.De Quervaint's thyroid did not differ from those in healthy contr-ols.There were positive correlation between SFN and T_3, T_4 values.The resultssuggested that thyroid hormones might have a direct effect on SFN synthesis,releaseor metabolism;SFN might be an useful index of therapeutic effectiveness in hyper-thyroidism and hypothyroidism patients,and semmed valuabie for differential diagn-osis in hyperthyroidism,hypothyroidism and simple goiter.
出处
《天津医药》
CAS
1991年第10期603-606,共4页
Tianjin Medical Journal
关键词
纤维连结蛋白
甲亢
甲减
serum fibronectin
hyperthyroidism
hypothyroidism
thyroid hormone
