摘要
蚓激酶能直接降解纤维蛋白原和纤维蛋白,激活纤溶酶原,具有类凝血酶及类纤溶酶样作用,但对凝血因子Ⅱ、Ⅴ、Ⅶ、Ⅷ,Ⅸ、Ⅺ、Ⅻ无明显作用。蚓激酶有望成为新的溶栓、抗栓药。
EPA(Earthworm Plasminogen Activator)is extracted from coelomic fluid ofearthworm.The fibrinogen and fibrin can be dissolved directly and plasminogenactivated by EPA in vitro or vivo.It was found that TT,KPTT prolonged,andPg,Fbg reduced in vivo,which suggested that EPA was a thrombin-like and plas-minogen-like enzyme.PT,TGT and Factor ⅩⅢ(ⅩⅢ)were neat normal,whichindicated that coagulant factors Ⅱ、Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅺ、ⅩⅢ were not obviously affected byEPA.EPA might be a new effective anticoagulant and thrombolytic agent.
出处
《天津医药》
CAS
1991年第2期73-75,共3页
Tianjin Medical Journal
关键词
蚓激酶
血液凝固
纤维蛋白溶解
protein kinases
blood coagulation
fibrinolysis blood
coagulation factors
