摘要
目的 探讨小剂量环孢素A为主的联合方案治疗难治性特发性血小板减少性紫癜 (ITP)的疗效。方法 环孢素A(CsA) 1～ 2mg·kg-1·d-1.泼尼松 30～ 40mg/d ,达 g·kg-1·d-1,每日 2或 3次口服 ,用药 2～ 3个月。肝素 2 0mg/d、分 2次腹部皮下注射 ,2 8日为 1个疗程 ,共 2个疗程。显效后以小剂量环孢素A和强的松维持治疗 1～ 2年。结果 显效 9例、良效 6例、无效 3例、总有效率 83 .3 % (15 / 18)。
Objective To study the effectiveness of the combined regime including low dose CsA in treatment refractory idiopathic thrombocytopenlc purpura(ITP). Methods Cyclosporin A(CsA) 1～2 mg·kg -1 · d -1 , prednisone(pred)30～40 mg·d -1 , and danazol 0.2～0.3 mg·kg -1 · d -1 , were given in divided doses for two to three months. Heparin 10 mg twice a day was given by subcutaneous injection over the abdomen for 28 days as one course, altogether two courses. Low dose CsA and prednisone were maintained for one or two years if the above regime was effective. Results Nine cases showed complete response, six showed partial response and three cases showed no response, the total efficacy was 83.3%(15/18). Conclusion The combined regime including low dose cyclosporin A(CsA) is effective in treatment of refractory idiopathic thrombocytopenlc purpura.
出处
《上海医学》
CAS
CSCD
北大核心
2002年第3期167-169,共3页
Shanghai Medical Journal
