摘要
目的:评价独活胶囊急性及长期毒效应,为临床安全用药提供毒理学依据。方法:按《中药新药研究指南》要求,应用昆明种小鼠经口进行急性毒性试验,应用Wistar大鼠和杂种犬进行90天经口长期毒性试验。结果:小鼠、大鼠大剂量给药后10分钟出现尾尖发绀、烦躁不安、呼吸加快等中毒症状,部分小鼠因呼吸衰竭而死亡,但大鼠给药30天后中毒症状消失;高剂量组大鼠生长较对照组缓慢,病理学检查可见部分大鼠胃胀气、粘膜水肿,光镜下可见高剂量组少数大鼠及犬肝细胞内有玻璃样小体出现,经恢复期观察此种改变为可逆的,基本恢复正常水平;各剂量组大鼠、犬的血液学、血液生化学各指标与对照组相比,均未发生有意义的变化,小鼠经口LD50为7.35±0.62g/kg。结论:独活胶囊属低毒类药物。
ve: To evaluate acute and long-time toxicity of angelicaroot capsule and provide the toxicology basis for safety using in clinical. Method: Mice of Kun Ming species were selected in acute toxicity experiment by mouth and Wistar rats and hybrid dogs were selected in 90 days long time toxicity experiment by mouth. Result: Mice and rats appeared tip cyanosis, agitated activity, quicken respiration after 10 minutes oftaking angelicaroot capsule. Several mice died because of failure of respiration. But toxicity symptoms of rats disappear after 30 days of taking angelicaroot capsule. The rats in higher dose angelicaroot capsule group grew slower than the rats in control group. It can be seen of gaseous distention in stomach, edema of mucous membrane in pathology inspection. In higher dose group, there were myeline bodies in liver cells of some rats and dogs, but it is reversible. There were not different between all angelicaroot capsule groups and control group in blood and biochemistry indexes of rats and dogs. LD50 of mice by mouth is 7.35±0.62 g·kg-1. Conclusion: Angelicaroot capsule belongs to lower class toxicity drug.
出处
《沈阳医学院学报》
2002年第1期4-9,27,共7页
Journal of Shenyang Medical College
关键词
独活胶囊
急性毒性
长期毒性
安全用药
angelicaroot capsule
acute toxicity
long time toxicity
mice
rat
dog
