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巨噬细胞炎性蛋白-1α与支气管哮喘 被引量：8

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摘要 巨噬细胞炎性蛋白－１α（ＭＩＰ－１α）作为一种Ｃ－Ｃ趋化因子对各种炎性细胞的特异性趋化和激活在哮喘气道炎症中发挥着重要的作用。当过敏原进入机体后募集和激活多种效应细胞如单核／巨噬细胞、淋巴细胞、嗜酸性粒细胞等到达呼吸道，被激活的细胞合成和释放ＭＩＰ－１α等趋化因子，ＭＩＰ－１α等趋化因子又参与激活和趋化Ｔ细胞和嗜酸性粒细胞，从而参与了哮喘的发病过程，这是一种循环效应。本文就ＭＩＰ－１α的生物学特性、生物学效应及其在支气管哮喘中的作用作一综述。
作者 张维溪
机构地区 温州医学院附属儿童医院
出处 《国外医学（儿科学分册）》 2002年第2期65-67,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 巨噬细胞炎性蛋白-1Α 支气管哮喘 趋化因子 生物学特性
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献17

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同被引文献80

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国外医学（儿科学分册）
2002年 第2期

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