摘要
目的 :探讨PTEN蛋白在儿童髓母细胞瘤中的表达及临床意义。方法 :采用免疫组化方法 ,检测 84例经手术病理证实并获随访的儿童髓母细胞瘤标本 (男 4 6例 ,女 38例 ,年龄 6～ 12岁 )中的PTEN表达 ,按术后生存期 3年、 5年、 10年分为A、B、C三组 ,使用Cox回归统计分析。结果 :PTEN阳性染色颗粒定位于细胞质中 ,在 84例标本中 ,有 4 3例 (5 1 2 % )PTEN呈阳性表达 ,A、B、C三组阳性表达为 2 8% ,6 6 6 % ,93 3% ,呈显著性差异 (差异 (P <0 0 1) ;Cox回归分析显示 ,PTEN是影响生存时间的一个独立预后的因子 ,它与预后存在高度正相关关系。结论 :PTEN基因突变或缺失在儿童髓母细胞瘤中的发生发展中起重要作用 ,且与患儿预后相关 。
Objective:To investigate the phos phatase and tensin homoeogy deleted on c hromosome ten(PTEN)protein expression and clinical significance of medulloblastoma in children.Method:The tum expressor PTEN in 84 pathologically confirmed medullo blastomas specimens in children with 3,5,10 ye ar survival(Group A,Group B,Group C,resp ectively)were studied by immunohistochemical technique and follow-up survey with Cox regression analysis.There were 46 males and 38 females,and aged 6 to 12 years.Resu lt:the PTEN positive staining was found in the plasma,the positive rate was 51 2%(43 /84),and the positive rates were increased w ith different groups( P <0 01).Cox regression showed that PTEN was an independent p rognostic factor affecting survival and h ad a close positive correlation with the prognosis.Conclusion:PTEN gene mutation and deletion played a key role in the gene sis and developmen of the medulloblastoma of child ren.it is considered a valuable predictable fa ctor for the medulloblastoma of children.
出处
《华西医学》
CAS
2002年第1期21-22,共2页
West China Medical Journal
关键词
PTEN
儿童
髓母细胞瘤
表达
预后
s:PTEN
Medulloblastoma
children expression prognosis
