摘要
应用人工肝支持系统 (血浆置换 +胆红素吸附 +血液透析 ) ,对 7例慢性重症肝炎患者进行治疗。经人工肝支持系统治疗后 ,患者症状好转 ,肝功能有所好转 [丙氨酸转移酶由 (15 9.49± 96 .6 9) U/ L 降至 (82 .42± 10 8.71) U/L,P<0 .0 5 ;血白蛋白由 (33.2 6± 2 .14) g/ L 升至 (37.0 6± 4.0 6 ) g/ L,P<0 .0 1;总胆红素由 (5 2 6 .0 4± 2 5 7.46 ) μm ol/L 降至 (389.19± 185 .2 6 ) μmol/ L,P<0 .0 0 1],尿素氮及血肌酐水平分别由 (2 4.41± 6 .5 1) mmol/ L 和 (334 .75±113.11) μm ol/ L 降至 (14.40± 5 .5 2 ) m mol/ L 和 (2 11.5 6± 6 4.0 8) μmol/ L,P<0 .0 0 1和 P<0 .0 1。 3例患者分别在治疗 1、 3、 6次后行肝移植存活 ,其中 1例在肝移植前停止人工肝支持系统治疗而肝功能稳定达 12 d。另 4例死亡。结果提示 ,人工肝支持系统是重症肝炎有益的治疗方法之一 。
Seven patients suffering from hepatitis gravis were treated with artificial liver support system (ALSS). The system was composed of plasma separation, bilirubin adsorbent column and hemodialysis. The results showed that liver function was significantly improved after ALSS therapy [ALT: (159.49±96.69) U/L vs (82.42±108.71) U/L,P<0.05;serum albumin: (33.26±2.14) g/L vs (37.06±4.06) g/L,P<0.01;total bilirubin: (526.04±257.46) μmol/L vs (389.19±185.26) μmol/L,P<0.001]. There was significant decreases of azotemia (blood urea and creatinine were decreased from (24.41±6.51) mmol/L and (334.75±113.11) μmol/L to (14.40±5.52) mmol/L and (211.56±64.08) μmol/L,respectively (both P<0.01). Three patients receiving orthotopic liver transplantation were alive after treatment for 1, 3, 6 time by ALSS and one of them was stable for 12 days without ALSS before transplantation. The remaining 4 patients was dead. The ALSS is effective in the treatment of hepatitis gravis and can improve general conditions of the patients before orthotopic liver transplantation.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2002年第2期156-158,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
