摘要
目的 :探讨迟发性膜迷路积水 (DEH)的临床特征及发病机制中内耳自身免疫性病理因素的作用。方法 :对 2 6例 (同侧性 19例 ,对侧性 7例 )DEH病人进行临床观察、听觉功能测试、非特异性和特异性免疫学试验及疗效分析。结果 :导致先期耳聋的常见病因有突发性聋、脑膜炎、麻疹、乳突手术等 ;6例病人出现针对内耳抗原的特异性免疫反应 ,其中 4例应用免疫抑制剂治疗有效。结论 :DEH与原发性感音神经性聋的间隔期差异大 ,导致先期感音神经性聋的病因较多。内耳自身免疫性病理因素在DEH发病中可能起着重要作用。
Objective To Investigating the clinical features of the delayed endolymphatic hydrops(DEH) and to study the possible role of autoimmune inner ear disorders in the pathogenesis of DEH.Methods Twenty six cases of DEH patients (19 ipsilateral,7 contralateral) involved in this research,whose clinical manifestations,hearing functions,specific (against inner ear antigens) and nonspecific immunoreaction,and curative effects (including medicine treatment,immunosuppressive agents treatment and vestibular neurotomy) were investigated.Results The common etiological factors inducing previous sensorineural hearing loss (SNHL) consisted of sudden deafness,meningitis,measles,and mastoidectomy etc.The specific immune responses against inner ear antigens were positive in 6 cases.The immunosuppressive agents proved effective in 4 cases.Conclusions There is a significant difference in the interval primary of SNHL and DEH.Many etiological factors could induce previous SNHL.Autoimmune inner ear disorders maybe play an important role in DEH pathogenesis.The pathological mechanism may be a kind of sympathetic labyrinthitis because there existed a specifically positive immune reaction and an effective treatment with immunosuppressive agents in these patients.
出处
《东南大学学报（医学版）》
CAS
2002年第1期65-68,共4页
Journal of Southeast University(Medical Science Edition)
基金
国家自然科学基金资助项目(3977093)。
关键词
膜迷路积水
自身免疫
梅尼埃病
交感性迷路炎
endolymphatic hydrops
autoimmune
Meniere's disease
sympathetic labyrinthitis
