摘要
观察急性痛风性膝关节炎家兔模型白细胞介素 8(IL 8)的变化及活血化瘀和清热解毒方药的干预作用。采用McCartyD .J[1] 方法建立家兔急性痛风性膝关节炎模型 ,应用酶联免疫试验 (ELISA)法 ,于造模后 2、6、9、12h测定其膝关节液中IL 8的水平。结果 ,中药干预组的IL 8水平显著低于模型对照组 ,差异显著 (P <0 0 5 )。结论 ,活血化瘀和清热解毒方药能显著降低急性痛风性膝关节炎家兔模型膝关节液的IL 8水平 。
Objective: To observe the changes of interleukin 8(IL 8) in knee joint of monosodium urate crystal induced rabbit arthritis and the interrupting effects of promoting blood circulation to remove stasis and clearing away heat and removing toxic substances. Methods :We created model of MSU induced rabbit acute arthritis according to Mc Carty D.J.method and detected the level of IL 8 in supernatants of synovial membrane and synovial fluids at 2h,6h,9h 12h by ELISA respectively. Results :The levels of IL 8 in TCM groups are significantly higher than that in model group( P <0 05). Conclusions :The prescriptions of promoting blood circulation to remove stasis and clearing away heat and removing toxic substances could significantly reduce the level of IL 8 in supernatants of MSU induced rabbit acute arthritis and had better preventing and curing effects.
出处
《辽宁中医杂志》
CAS
2002年第4期244-245,共2页
Liaoning Journal of Traditional Chinese Medicine
