摘要
阿尔采末病 (AD)是一个复杂的病理生理过程 ,脑特异性炎症反应在其发病中起重要作用 ,有多种炎症细胞因子的参与 ,如IL 1、IL 6、TNF α和TGF β等。这些细胞因子在AD患者的脑中表达都明显地增加 ,可以激活小胶质细胞(MC)和星形细胞 (AC) ,活化的MC和AC又可引起炎症细胞因子产生 ,它们共同参与脑局部炎症过程 ,与神经纤维缠结和老年斑的形成密切相关。
Inflammatory response clearly occured in pathologically vulnerable regions of the Alzheimers disease (AD) brain. Many proinflammatory mediators, such as IL-1, IL-6,TNF-α and TGF-β, were significantly up-regulated in the pathophysiological process of AD. In addition to their traditional actions as proinflammatory molecules, AD-specific interactions of the cytokines and amyloid β(Aβ) may be pathophysiologically relevant, and there was a reciprocal relationship within the cytokines inducing and being induced by Aβ.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2002年第1期1-5,共5页
Chinese Pharmacological Bulletin
